Antimicrobial resistance (AMR) poses a significant global health challenge. The widespread misuse and overuse of antibiotics have accelerated the emergence of drug-resistant pathogens. Such pathogens can render standard treatments ineffective, leading to prolonged illness, higher healthcare costs, and greater mortality. AMR complicates the management of infections, particularly in healthcare settings, and limits the effectiveness of surgical procedures. To combat AMR, natural plant extracts with their rich antimicrobial properties can be a sustainable alternative to fight AMR. Their diverse modes of action can reduce resistance development, and synergistic effects with antibiotics may enhance treatment efficacy. Incorporating nano-engineering into plant extracts creates a robust strategy against AMR, particularly for vulnerable populations, by enhancing their bioavailability and delivery efficiency. These nano-sized antimicrobials can overcome drug resistance mechanisms more effectively than conventional antibiotics alone. This approach could revolutionise infection management and contribute to overcoming the limitations imposed by AMR on healthcare systems.