Li Group
Programmable Biomineral Composites for Precision Therapeutics and Sustainable Agriculture
The Advanced Programmable Biominerals Group, led by Dr Li Li, stands out for its innovative integration of precision nanotechnology with real-world applications in healthcare and agriculture.
Our unique approach centers on the precision assembly of polymers and inorganic nanoparticles to create advanced, responsive biomineral composites. By developing smart delivery systems for drugs, pesticides, and fertilizers, we address critical challenges and contribute to advancements in both medical treatments and agricultural productivity.
In healthcare, our research seeks to develop cutting-edge solutions for targeted drug/gene/protein delivery and controlled release systems. These nanocomposites are designed to respond to specific physiological environments to overcome the biological barriers, providing exceptional precision in therapeutic applications. This approach enhances treatment efficacy while minimizing side effects, particularly for cancer and infectious disease.
In agriculture, our focus is on creating smart delivery systems for RNAi, pesticides, fertilizers to improve efficiency and sustainability. By utilizing these advanced biominerals, we promote soil health, enhance crop yield, and reduce environmental impact. Our innovative solutions address critical challenges in modern agriculture, contributing significantly to food security and environmental sustainability.
Research Areas
- Functional nanomaterials
- Precision nanomedicine
- Control release
- Oral drug/vaccine development
- Sustainable agriculture
- RNAi nanotechnology
Research Approach
Dr Li and her team have developed programmable biomineral nanoparticles using advanced nano-engineering techniques. These unique nanoparticles are engineered with pH-, enzyme-, and light-responsive properties to overcome biological barriers for more effective treatments.
- Smart RNA-Based Technologies: Efficient delivery of siRNA, mRNA, microRNA, and DNA for gene therapy, disease prevention, and crop improvement, including Bioclay technology for sustainable pest management.
- Precision Nanomedicine: Biomimetic nanocomposites for personalized therapies, integrating photothermal and photodynamic therapies for improved cancer treatment and exploring vaccine delivery.
- Mucosal Delivery Systems: Advanced oral and nasal delivery systems for drugs and vaccines, enhancing bioavailability and patient compliance.
- Natural Product Development: Novel therapeutic agents against infectious diseases and antimicrobial resistance using bioactive compounds from natural sources.
- Slow-Release Agricultural Technologies: Optimising nutrient and pesticide delivery to crops, promoting sustainable agricultural practices and improving crop yield.
Research Highlights
Media
- Waste to Wealth by transforming agricultural waste into high-quality soil products for mushroom cultivation and crop growth.
- ARC Research Hub for Value-added Processing of Underutilised Carbon Waste.
- Qld fellowships fund researchers with global vision
- Green feel for collaboration with China
Collaborations
Li has established broad collaborations with national and international researchers on nanomaterials and healthcare from the USA, China, Switzerland and New Zealand, etc. She has a strong linkage with industry partners on the development of functional targeted nano-delivery systems to enhance the health of farm animals. She worked on RIRDC and Research Connections projects with industry partners.
Research Projects
PhD opportunities
Funding
Since 2019
- ARC Mid-Career Industry Fellowship (2025 - 2028)
- UQ HERA2.0-mRNA Vaccine (2023 - 2028)
- ARC Hub (2024 - 2029)
Publications
Click here to view Li group publications
