Project Summary

Polyisocyanopeptide (PIC)-based hydrogel functionalised with tri-ethylene glycol is an ideal scaffold for wound healing approaches as it is a liquid that solidifies at body temperature enabling easy application to complex wound sites and their mechanical responsiveness mimics that of biopolymers. This project is focused on using PIC hydrogel as the matrix for therapeutic wound dressings and by conjugation of bioactive molecules, promote wound healing by bringing about hemostasis as well as disinfection and stimulation of subsequent healing.

Immune Synapse Formation
Bio-functionalised polyisocyanopetide based hydrogel for use in hemostasis (blood coagulation) the first stage of wound healing.

Research Group

Rowan Group

Keywords

bio-conjugation, hydrogel, wound healing, hemostasis, dressings

Available Student Projects

Lighting up snake venom proteins: fluorescently tag procoagulant to monitor movement at wound sites during blood clotting.

Tackling Coagulopathy (uncontrolled bleeding), a major cause of trauma-related deaths using hydrogel based wound dressings

Really get to know your snake venom proteins: investigation of procoagulant’s blood clotting activity and the effect of the disintegrin and ADAM domains, as well as the effect of metal ions on this pro-coagulant metalloprotease.

 

Project members

Lead Investigator


Professor Alan Rowan

AIBN Institute Director
Senior Group Leader
Rowan Group

Dr Amanda W. Kijas

Postdoctoral Research Fellow
Rowan Group

Researchers Involved


Dr Jan Lauko

Postdoctoral researcher - Group operations manager
Rowan group

Joyce Elisabeth Pauline Brouns

Occupational Trainee
Rowan Group

Dr Ekaterina Nam

Postdoctoral Research Fellow
Rowan Group

Dr Petri Turunen

Postdoctoral Research Fellow
Rowan Group

External to AIBN


Dr Lambro Johnson, Dr Paul Masci, Professor John de Jersey, Professor Martin Lavin, Dr Kong-Nan Zhao.