Dr Nathan Gödde
Manager - The Australian Organoid Facility
Wolvetang Group
+61438061797
Dr Nathan Gödde has a special interest in harnessing advances in automation, genetic engineering, and stem cell technology to develop sophisticated models of development and disease.
Nathan spent several years utilising genetically engineered mouse models and 3D organotypic assays to understand the links between development and disease. This research examined the role of polarity genes in breast cancer with a paticular focus on epithelial morphogenesis, stem/progenitor cell biology, tumour progression, and heterogeneity.
He then adapted stem cell-derived tissue cultures to model infection of risk group 3 and 4 pathogens such as Hendra Virus, Rabies and SARS-CoV-2.
Nathan now utilises advanced automation technologies to support other researchers interested in using 3D complex biological systems.
Nathan performed contract research for 6 years generating proteins and antibodies for biotechnology clients. He then completed his PhD at the University of Melbourne (Dept. of Surgery) investigating the molecular links between brain cancer cells with the tissue environment.
He performed research on polarity gene defects in cancer in the laboratory of Prof. Patrick Humbert at the Peter MacCallu Cancer Centre and the Latrobe Institure of Molecular Science, before joining CSIRO to perform research on highly pathogenic viruses using stem cell and organoid models.
During this time Nathan also performed contract research for biotechnology clients interested in 3D culture systems and managed a cell culture facility supplying cells for ISO17025 diagnostic laboratories.
Nathan now manages the Australian Organoid Faciltiy at the AIBN, an automation laboratory specialising in organoid production services for Queensland researchers.
Key Publications
Gödde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE, Humbert PO. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet. 2014 May 22;10(5):e1004323. doi: 10.1371/journal.pgen.1004323.
McAuley AJ, Jansen van Vuren P, Mohammed MU, Faheem, Goldie S, Riddell S, Gödde NJ, Styles IK, Bruce MP, Chahal S, Keating S, Blasdell KR, Tachedjian M, O'Brien CM, Singanallur NB, Viana JN, Vashi AV, Kirkpatrick CM, MacRaild CA, Shah RM, Vincan E, Athan E, Creek DJ, Trevaskis NL, Murugesan S, Kumar A, Vasan SS. Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection. Viruses. 2022 Oct 31;14(11):2417. doi: 10.3390/v14112417.
Farr RJ, Gödde N, Cowled C, Sundaramoorthy V, Green D, Stewart C, Bingham J, O'Brien CM, Dearnley M. Machine Learning Identifies Cellular and Exosomal MicroRNA Signatures of Lyssavirus Infection in Human Stem Cell-Derived Neurons. Front Cell Infect Microbiol. 2021 Dec 24;11:783140. doi: 10.3389/fcimb.2021.783140.
Dall GV, Vieusseux J, Seyed-Razavi Y, Gödde N, Ludford-Menting M, Russell SM, Ashworth A, Anderson RL, Risbridger GP, Shackleton M, Britt KL. Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24 + CD29/CD49fhi in mice. Breast Cancer Res Treat. 2020 Oct;183(3):565-575. doi: 10.1007/s10549-020-05804-1. Epub 2020 Jul 21.
Smith P, Gödde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L. VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. Sci Rep. 2019 May 8;9(1):7079. doi: 10.1038/s41598-019-43444-8.