Dr Jie Tang’s research focuses on developing nanoparticle platforms with unique nanostructure and surface chemistry for biomedical applications, i.e. drug delivery (small molecules, nucleic acids, and proteins), cancer immunotherapy, and vaccine adjuvants

Nanomaterials-based Cancer therapy and immunotherapy. By understanding the complicated tumor micro-environment, Dr Jie Tang is developing innovative materials (e.g., openwork@dendritic mesoporous silica nanoparticles, disulfide-bond-incorporated mesoporous organosilica nanoparticles, and ultra-small nanochelators, tumour targeting lipid calcium phosphate nanoparticles) and strategies (e.g., lactate depletion, immunogenic cell death improvement, bioavailable copper depletion, and photothermal therapy combined with gene therapy) for advanced cancer therapy and immunotherapy. (2) Engineering biomimetic nanoplatform for oral delivery. Development of novel biomimetic drug delivery platform based on nanoparticles with engineered morphology/architecture, micicking gut microbes to achieve enhanced mucus penetration and transcytosis through intestinal epithelium. (3)Nanoadjuvants development.By combining state-of-the-art nanotechnology and classical coordination chemistry, we develop new generation aluminosilicate nanoadjuvants with improved efficacy and safety over current market Alum-based adjuvants (which do not activate cellular mediated immunity). The core technology is being patented with industrial partner who has launched ‘NUVEC’, an adjuvant delivery system for cancer vaccines.

Dr Jie Tang received her BSC in 2010 and MSC in 2013 from the West China School of Pharmacy, Sichuan University, China. In 2018, she received her PhD degree from The University of Queensland, Australia. In 2016, she worked as a visiting Scientist at Department of Pediatrics, Ludwig-Maximilians University of Munich, Germany, and School of Pharmacy, UCL, UK. Currently, she works as an Advanced Queensland Industry Research Fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN), the University of Queensland. 

Industry

Dr Jie Tang actively led the translation efforts of these technology by liaising with industry partners: (1) In collaboration with Ridley Agriproducts, a major Australian producer of animal nutrition products, she is developing an antibiotic-free animal feed technology and an animal nutrition enhancer product from bench to market. (2) She also expanded its application to an antigen delivery system in feed additives for poultry infection control with multiple industrial partners with conferral of an AQIRF fellowship. (3) The development of DNA vaccines in collaboration with N4 Pharma and MedImmune.

Collaborations

Examples of collaborations with academia include Prof Wayne L. Bryden from School of Agriculture and Food Sciences, UQ to apply the Nanoadjuvant Technology in nano-vaccine delivery for livestock healthcare; Prof Joseph Rosenecker from the Department of Pediatrics, Ludwig-Maximilians-University of Munich, and Prof Shan Guan from the National Engineering Research Center of Immunological (China) on mucosal vaccine delivery products; Prof. Haoxing Wu from West China Medical School, Sichuan University to develop innovative nanostructures for imaging guided cancer therapy. Dr Jie Tang also engaged in the commercialisation of the patented Nanoadjuvant Technology through collaborations with multiple industrial partners as described previously.
 

Key Publications

Tang, Jieet al., Openwork@ Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation. Angewandte Chemie International Edition. 132.49 (2020): 22238-22246.

Yang, Y., Tang, J., Song, H., Yang, Y., Gu, Z., Fu, J., ... & Yu, C. (2020). Dendritic mesoporous silica nanoparticle adjuvants modified with binuclear aluminum complex: coordination chemistry dictates adjuvanticity. Angewandte Chemie International Edition59(44), 19610-19617.​

Dai, Zan, Tang, Jieet al., (co-1st authors). "Eliciting Immunogenic Cell Death via a Unitized Nanoinducer." Nano Letters, 2020. doi:10.1021/acs.nanolett.0c00713

Yang, Y., Tang, Jie, et al., (co-1st authors). Responsively Aggregatable Sub-6 nm Nanochelators Induce Simultaneous Antiangiogenesis and Vascular Obstruction for Enhanced Tumor Vasculature Targeted Therapy. Nano letters 19, no. 11 (2019): 7750-7759.

Tang, Jieet al., Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy[J]. Biomaterials, 2019: 119232. 

Funding

Tang, J. “Green Nanotechnology-based Antibiotic-free Poultry Feed Against Coccidiosis”. Advance Queensland Industry Research Fellowship, 2020. 
Tang, J., et al. “Nanoparticle-based animal feed additives”. Ridley Research Project, 2018.