Nanoparticle platforms for biomedical applications: manipulating the nano-bio interface
Nanotechnology has emerged as a promising approach for precision diagnosis and treatment of life-threatening diseases. Dr Jie Tang's research is dedicated to both fundamental and applied research at the nano-bio interface through nanomaterial innovation, focused on the central theme of delivery of various active molecules for therapeutic benefit. She has multi-disciplinary expertise that bring together biomedical engineering, pharmaceutics, and nanotechnology in developing nanoparticle platforms for drug delivery, cancer immunotherapy and vaccine adjuvants, and achieved 40 research outputs, including patents. Her capacity to conduct high-quality innovative research is evidenced by >94% of her studies published in top 10% journals in Chemistry, Materials Science, Pharmaceutical Science, Medicine, & Biotechnology (SJR). Her research pioneers the new concept that unique surface nanostructure and chemistry of nanoparticles significantly impacts cell behaviour and have been adopted for new nanoparticle-based drug screening platform, drug delivery system, vaccine adjuvant and disease detection.
Collaborations and Industry Engagement
Jie has built collaborations with a number of active researchers from UQ, UNSW, the University of Melbourne, Ludwig-Maximilians-University of Munich (Germany), National Engineering Research Center of Immunological (China), West China Medical School, Chinese Academy of Sciences, and the University of North Carolina at Chapel Hill (USA).
Funding
- Tang, J, “Fighting Cancer Relapse: Developing an Oral Cancer Vaccine Generating Memory T Cells”. NHMRC Investigator Grants Emerging Leadership 1 (2023-2028)
- Tang, J. “Green Nanotechnology-based Antibiotic-free Poultry Feed Against Coccidiosis”. Advance Queensland Industry Research Fellowship, 2020-2023
- Tang, J. N4 Pharm Research Project (2019)
- Tang, J., et al. Ridley Research Project (2018)
Key Publications
(*Corresponding author)
- Dai, Zan, Qiaoyun Wang, Jie Tang*, Rui Qu, Min Wu, Haoze Li, Yannan Yang, Xu Zhen, and Chengzhong Yu*. "A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy." Biomaterials 284 (2022): 121533.
- Jie, Tang, Yang Yang, Jingjing Qu, Wenhuang Ban, Hao Song, Zhengying Gu, Yannan Yang et al. "Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity." Chemical science 13, no. 29 (2022): 8507-8517. (Front Cover article)
- Tang, Jie, Anand Kumar Meka, Shevanuja Theivendran, Yue Wang, Yannan Yang, Hao Song, Jianye Fu et al. "Openwork@ dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation." Angewandte Chemie 132, no. 49 (2020): 22238-22246.
- Yang, Yang, Jie Tang*, Hao Song, Yannan Yang, Zhengying Gu, Jianye Fu, Yang Liu, Min Zhang, Zhen‐An Qiao, and Chengzhong Yu. "Dendritic mesoporous silica nanoparticle adjuvants modified with binuclear aluminum complex: coordination chemistry dictates adjuvanticity." Angewandte Chemie 132, no. 44 (2020): 19778-19785.
- Tang, Jie, Bei Li, Christopher B. Howard, Stephen M. Mahler, Kristofer J. Thurecht, Yilun Wu, Leaf Huang, and Zhi Ping Xu. "Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy." Biomaterials 216 (2019): 119232.
- Tang, Jie, et al., Openwork@ Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation. Angewandte Chemie International Edition. 132.49 (2020): 22238-22246.
- Yang, Y., Tang, J., Song, H., Yang, Y., Gu, Z., Fu, J., ... & Yu, C. (2020). Dendritic mesoporous silica nanoparticle adjuvants modified with binuclear aluminum complex: coordination chemistry dictates adjuvanticity. Angewandte Chemie International Edition, 59(44), 19610-19617.
- Dai, Zan, Tang, Jie, et al., (co-1st authors). "Eliciting Immunogenic Cell Death via a Unitized Nanoinducer." Nano Letters, 2020. doi:10.1021/acs.nanolett.0c00713
- Yang, Y., Tang, Jie, et al., (co-1st authors). Responsively Aggregatable Sub-6 nm Nanochelators Induce Simultaneous Antiangiogenesis and Vascular Obstruction for Enhanced Tumor Vasculature Targeted Therapy. Nano letters 19, no. 11 (2019): 7750-7759.
- Tang, Jie, et al., Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy[J]. Biomaterials, 2019: 119232.