Engineered Nanostructured Superparamagnetic Nanoparticles for the Isolation and Detection of Disease-Specific Biomolecules

​The research endeavors is to the development of superparamagnetic nanoparticles based novel approaches and integrated devices for the ultra-sensitive detection of trace amounts biomolecules (or biomarkers). This will be achieved with the following specific objectives; i) synthesis and characterization of nano-porous superparamagnetic nanoparticles (NPs), ii) analysis of plasmonic and electrochemical characterization of the NPs, iii) functionalization of NPs with biomolecules for capturing target biomolecules from clinical samples, and iv) nanoengineered NPs integrated POC device for molecular diagnostics. 

Mostafa Kamal Masud has completed his B.Sc. and M.S. from the Department of Chemistry, Shahjalal University of Science and Technology, Sylhet, Bangladesh. He had started his PhD research on the development of engineered nanostructured superparamagnetic materials based molecular diagnostics for the detection of disease-specific (Cancer and MND) biomolecules at the Australian Institute for Innovative Materials, University of Wollongong (UoW), NSW-2522. Recently he has enrolled in Australian Institute for Bioengineering and Nanotechnology, the University of Queensland (UQ), QLD 4072 as a PhD student and continuing his PhD research. He is also affiliated as a visiting scholar with the Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan Campus, QLD-4111, Australia. Moreover, prior to coming UoW, he was serving as a faculty member at the Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh.

Industry Engagement

​AINSE Post-Graduate Research Awards-2018, Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights NSW 2234.

Key Publications

  1. Masud, M.K., Yadav, S., Islam, M.N., Nguyen, N.T., Salomon, C., Kline, R., Alamri, H.R., Alothman, Z.A., Yamauchi, Y., Hossain, M.S.A. and Shiddiky, M.J., Gold-Loaded Nanoporous Ferric Oxide Nanocubes with Peroxidase-Mimicking Activity for Electrocatalytic and Colorimetric Detection of Autoantibody. Analytical Chemistry, 2017, 89, 11005-11013
  2. Masud, M.K., Islam, M.N., Haque, M.H., Tanaka, S., Gopalan, V., ALICI, G., Nguyen, N.T., Lam, A.K.Y., Hossain, M.S., Yamauchi, Y. and Shiddiky, M.J., Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA,  Chemical Communications, 2017, 53, 8231-8234
  3. Hossain, T.,1 Mahmudunnabi, G.,1 Masud, M.K.,1 Islam, M.N., Ooi, L., Konstantinov, K., Al Hossain, M.S., Martinac, B., Alici, G., Nguyen, N.T. and Shiddiky, M.J., Electrochemical biosensing strategies for DNA methylation analysis, Biosensors and Bioelectronics, 2017, 94, 63-73. (1equal contributor).
  4. Yadav, S., Masud, M.K., Islam, M.N., Gopalan, V., Lam, A.K., Tanaka, S., Nguyen, N.T., Hossain, M.S., Li, C., Yamauchi, Y. and Shiddiky, M.J., Gold-Loaded Nanoporous Iron Oxide Nanocubes: A Novel Dispersible Capture Agent for Tumor-Associated Autoantibodies Analysis in Serum, Nanoscale, 2017, 9, 8805-8814
  5. Islam, M.N., Masud, M.K., Nguyen, N.T., Gopalan, V., Alamri, H.R., Alothman, Z.A., Al Hossain, M.S., Yamauchi, Y., Lam, A.K.Y. and Shiddiky, M.J., Gold-loaded nanoporous ferric oxide nanocubes for electrocatalytic detection of microRNA at attomolar level. Biosensors and Bioelectronics, 2018, 101, 275-281.