Nanoarchitectured point-of-care detection system for clinically relevant disease biomarkers

​Mostafa Kamal Masud is a PhD candidate (has already finished the thesis review milestone and preparing the thesis for submission) at the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Australia. His research focuses on the design and translation of bio-favourable engineered nanostructured superparamagnetic materials towards the development of molecular diagnostics (optical and electrochemical nanobiosensors, magnetophoretic-based and paper-based microfluidic devices) for cancer.  During his PhD, he has successfully synthesised different magnetic nanostructure and nanostructure electrode, which are utilised to develop proof-of-concept (POC) assay for detecting disease-specific biomarkers (microRNA, autoantibody and exosome). The nanostructures are electrocatalytic towards redox molecule and employed for either isolating target molecules and/or amplified signal transduction, thereby providing higher detection sensitivity.  The developed methods eliminate the cumbersome PCR and enzymatic amplification steps as well as simplifies the assay building by avoiding multiple measures involved in conventional biosensing approaches through recognition and transduction layers. He envisages that these methods linked porous nanostructures and bio-detection sensitivity will aid the development of high-performance diagnostic tools for clinics.

​Mr Masud has completed his B.Sc. and M.S. from the Department of Chemistry, Shahjalal University of Science and Technology, Sylhet, Bangladesh. During his PhD at AIBN, UQ, his research has resulted in the development of new knowledge in detection-technology, which published in several leading journals including Chemical Society Review, Analytical Chemistry, Small, ACS Nano, Biosensor & Bioelectronics, Nanoscale etc. In recognition of his contribution to the field of mesoporous nanostructure for biosensing and research excellence, he has received several awards including; postgraduate research award (PGRA) from AINSE Limited (the Australian Institute of Nuclear Science and Engineering), Sydney; first Prize for Outstanding Poster from AINSE/ANBUG Neutron Scattering Symposium 2018, Sydney; Analytical Methods Poster Prize from 21st Australia and Newzealand Electrochemistry Symposium 2019, Brisbane, Australia.  Prior to starting his PhD, he was serving as a faculty member at the Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh.

Industry

​AINSE, Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights NSW 2234.

Collaborations

ANSTO (Australia's Nuclear Science and Technology Organisation), Sydney

QMNC (Queensland Micro Nanotechnology Centre) Griffith University

UQCCR (Centre for Clinical Research - University of Queensland) and

School of Pharmacy, UQ.

Key Publications​

Masud, M.K., Na, J. Younus, M, Hossain, M.S.A., Bando, Y., Shiddiky, M.J.A, and Yamauchi, Y., Superparamagnetic nanoarchitectures for disease-specific biomarker detection, Chemical Society Review.  2019 (DOI: 10.1039/c9cs00174c).

Masud M.K., Kim J, Billah MM, Wood K, Shiddiky MJ, Nguyen NT, Parsapur RK, Kaneti YV, Alshehri AA, Alghamidi YG, Alzahrani KA., Nanoarchitectured peroxidase-mimetic nanozymes: mesoporous nanocrystalline α-or γ-iron oxide?, Journal of Materials Chemistry B2019, 7, 5412-22.

Masud, M.K., Umer, M., Hossain, M.S.A., Yamauchi, Y., Nguyen, N.T. and Shiddiky, M.J.A., Nanoarchitecture Frameworks for Electrochemical miRNA Detection, Trends in biochemical sciences2019, 44, 433-452.

Masud, M.K., Yadav, S., Islam, M.N., Nguyen, N.T., Salomon, C., Kline, R., Alamri, H.R., Alothman, Z.A., Yamauchi, Y., Hossain, M.S.A. and Shiddiky, M.J., Gold-Loaded Nanoporous Ferric Oxide Nanocubes with Peroxidase-Mimicking Activity for Electrocatalytic and Colorimetric Detection of Autoantibody. Analytical Chemistry2017, 89, 11005-11013.

Masud, M.K., Islam, M.N., Haque, M.H., Tanaka, S., Gopalan, V., ALICI, G., Nguyen, N.T., Lam, A.K.Y., Hossain, M.S., Yamauchi, Y. and Shiddiky, M.J., Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA,  Chemical Communications2017, 53, 8231-8234.

Full list of publications available on espace