Development of diagnostic nanotechnologies for precision medicine

​Alain’s research focuses on the development of novel analytical and diagnostic tools that harness nanotechnology and microfluidics; two rapidly growing fields with high potential to provide diagnostic solutions needed for precision medicine. Alain’s research background lies in separation science, microfluidics, and biosensing and a feature of his work has been the ability to exploit these areas for cancer diagnostics. Currently, his research focuses on the development of highly sensitive and multiplexed nanoplatforms to study the role extracellular vesicles heterogeneity in cancer, monitor cancer immune therapy, and detect aberrant protein phosphorylation and DNA methylation in different cancer types.

​Alain completed his PhD at the University of Tasmania in 2016, after which he was awarded a Swiss National Science Foundation Fellowship to join Prof Matt Trau’s Group at the Centre for Personalised Nanomedicine to research electrohydrodynamic fluid flows for electrochemical biosensing. In 2018, Alain was awarded a UQ Development Fellowship to lead a research program on the development of diagnostic nanoplatforms for precision medicine with a particular focus on cancer biomarker detection from liquid biopsies.

Collaborations

​Alain has built a national collaborative network with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute, and the University of Tasmania.

Funding

2018-2021: UQ Development Fellowship

2019: UQ ECR grant

2016-2018: Swiss National Science Foundation Fellowship

Key Publications

  1. Wuethrich, A.; Sina, A. A. I.; Ahmed, M.; Lina, T.-Y.; Carrascosa, L. G.; Trau, M. Interfacial Nano-Mixing in a Miniaturised Platform Enables Signal Enhancement and in Situ Detection of Cancer Biomarkers. Nanoscale 2018, 10, 10884–10890.
  2. Dey, S.; Koo, K.; Wang, Z.; Sina, A. A. I.; Wuethrich, A.; Trau, M. An Integrated Multi-Molecular Sensor for Simultaneous BRAFV600E Protein and DNA Single Point Mutation Detection in Circulating Tumour Cells. Lab Chip 2019. 19, 738-748 
  3. Wuethrich, A.; Haddad, P. R.; Quirino, J. P. Green Sample Preparation for Liquid Chromatography and Capillary Electrophoresis of Anionic and Cationic Analytes. Anal. Chem. 2015, 87.
  4. Kamil Reza, K.; Dey, S.; Wuethrich, A.; Korbie, D.; Ali, A.; Sina, I.; Wang, Y.Trau, M. Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay. 2018, 39, 18484-18491. 
  5. Wuethrich, A.; Howard, C. B.; Trau, M. Geometric Optimisation of Electrohydrodynamic Fluid Flows for Enhanced Biosensing. Microchem. J. 2018, 137, 231–237.

Full list of publications available HERE