Developing models to understand and treat MND using induced pluripotent stem cells (iPSCs)
Duration:
January 2018–December 2020
Project Summary
Neurones are particularly active cells that continuously send signals around the body; this large workload places a considerable metabolic load on the neurones. If the energy demands of the neurones are not met, they will ultimately falter, and die.
In this project, we are developing iPSC-derived neurones from MND and non-MND subjects to assess neuronal bioenergetics. Insights gained from these iPSC-derived neurones will allow us to determine the impact of neuronal bioenergetics on disease pathogenesis. Using these iPSC-derived neurones, we aim to develop a high-throughput platform that will allow us to screen potential therapeutic candidates in MND, with the view to prevent neuronal death and thus, halt or slow disease progression in MND.
