Project Summary

Neurones are particularly active cells that continuously send signals around the body; this large workload places a considerable metabolic load on the neurones. If the energy demands of the neurones are not met, they will ultimately falter, and die.

In this project, we are developing iPSC-derived neurones from MND and non-MND subjects to assess neuronal bioenergetics. Insights gained from these iPSC-derived neurones will allow us to determine the impact of neuronal bioenergetics on disease pathogenesis. Using these iPSC-derived neurones, we aim to develop a high-throughput platform that will allow us to screen potential therapeutic candidates in MND, with the view to prevent neuronal death and thus, halt or slow disease progression in MND.

Day 60 human iPSC-derived neurons express the postmitotic neuronal marker NeuN (red), and the neuronal mictrotubule marker βIII-tubulin (green).

 

Research Group

Ngo Group

Keywords

Motor Neurone Disease

Project members

Lead Investigator


Dr Shyuan Ngo

Group Leader
Ngo Group

Reserchers Involved


Professor Ernst Wolvetang

Senior Group Leader
Wolvetang Group
UQ-StemCARE Director

Timothy Tracey

PhD Student
Wolvetang Group