Development of adjuvant-combined vaccines for enhanced humoral and cellular immune responses
Project summary
Current vaccines can prevent many infectious diseases but are ineffective against cancers and diseases such as malaria and HIV. This project will use a novel nanoparticle vaccine delivery platform to regulate the function of dendritic cells (DCs), a key player for immune responses. Antigens and adjuvants that boost the immune response (such as CpG, polyI:C, LPS) and siRNAs will be assembled onto layered double hydroxide (LDH) nanoparticles and their effects on DC-mediated T cell activation will be investigated. This project will help develop more efficient adjuvant combinations to enhance immune responses, enabling the design of new generation vaccines.
Research Group
Keywords
Nanomaterials, nanobiotechnology, health, vaccine, combination, adjuvants, Th1 and Th2, nanoparticle, dendritic cells, immune response, cytokines
Available Student Projects
Development of LDH-combined vaccines for enhanced humoral and cellular immune responses
