Development of superior sentinel lymph node mapping magnetic tracers for the clinical detection of lymph node metastasis

 Supervisor Dr Ruirui Qiao

Cancer metastasis occurs via migration of cancer cells through the lymphatic system. The possibility of early detection of lymph node metastasis shows a great potential for improving the quality of life for cancer patients and better prognosis. In order to improve the sensitivity of diagnosis, this project aims to develop biocompatible magnetometer probe that can specifically recognise the lymphatic metastasis, thereby providing an ultrasensitive technique for the transcutaneous detection of sentinel lymph node.

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“Smart” nanohybrid materials as effective drug delivery systems (DDS) for the controlled delivery of therapeutic agents to brain

 Supervisor Dr Ruirui Qiao

Inspired by natural activatable molecules, “smart” nanohybrid materials that are responsive to endogenous or exogenous stimuli, and interact with or are actuated by them, have brought extensive attentions for development of next generation imaging agents or carriers. This project aims to develop advanced inorganic/organic nanohybrids; and such nanohybrids are expected to have tailored physicochemical properties and can intelligently respond to remote triggers for the controlled delivery of therapeutic agents (drugs, siRNA etc.) for the treatment of brain cancer.

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Building 3D brain organoid models of brain cancer to improve early screening methods for nanotheragnostics

 Supervisor Dr Ruirui Qiao

Brain cancer is the leading cause of cancer related mortality in people under the age of 40. The design and synthesis of original, more targeted therapeutics, as well as the development of clinically relevant in vitro test models of brain cancer is urgently needed. For this project, you will build and characterise the formation and structural identity of a brain cancer organoid. The organoid that you develop will ultimately be used as a state-of-the art test platform for future in vitro studies; studies that are aimed at determining the efficacy of a theragnostic nanoparticle-siRNA therapeutic specifically designed and developed to target brain cancers. 

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Design and development of representative brain organoids during health and following the progressive establishment of Alzheimer’s disease

 Supervisor Dr Ruirui Qiao

Alzheimer’s disease is a progressive neurodegenerative disease that leads to severe cognitive decline. Alzheimer’s can develop in adults at any time, although onset is most associated with people over the age of 65. A full picture of what causes Alzheimer’s pathogenesis is still to be determined and as it stands, there is no definitive cure. Therefore, the development of more sophisticated clinically replicative in vitro test models of Alzheimer’s disease for the examination of new therapies that can inhibit, slow down disease progression, or readily complement existing treatment regimens are paramount. For this project, you will build a 3D brain organoid model encompassing Alzheimer’s disease effected neuronal cells. The aims of the project will be to characterise the effect of disease progression and investigate how this affects the architecture of the organoid brain model over time. The information obtained from this project will help to determine whether these organoids are a highly realistic in vitro model of Alzheimer’s disease and if they can be used as a test platform for future Alzheimer’s specific nanoparticle led treatments strategies.
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Group Leader: Dr Ruirui Qiao
   07 334 63152
  r.qiao@uq.edu.au

What to do

  1. Review each project description and find one which matches your areas of interest.
  2. Contact the project advisor directly to discuss the project and arrange a meeting or visit to the AIBN lab.

Contact 

AIBN Engagement Officer
aibn.events@uq.edu.au
07 334 64215

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