Development of superior sentinel lymph node mapping magnetic tracers for the clinical detection of lymph node metastasis

 Supervisor Dr Ruirui Qiao

Cancer metastasis occurs via migration of cancer cells through the lymphatic system. The possibility of early detection of lymph node metastasis shows a great potential for improving the quality of life for cancer patients and better prognosis. In order to improve the sensitivity of diagnosis, this project aims to develop biocompatible magnetometer probe that can specifically recognise the lymphatic metastasis, thereby providing an ultrasensitive technique for the transcutaneous detection of sentinel lymph node.

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“Smart” nanohybrid materials as effective drug delivery systems (DDS) for the controlled delivery of therapeutic agents to brain

 Supervisor Dr Ruirui Qiao

Inspired by natural activatable molecules, “smart” nanohybrid materials that are responsive to endogenous or exogenous stimuli, and interact with or are actuated by them, have brought extensive attentions for development of next generation imaging agents or carriers. This project aims to develop advanced inorganic/organic nanohybrids; and such nanohybrids are expected to have tailored physicochemical properties and can intelligently respond to remote triggers for the controlled delivery of therapeutic agents (drugs, siRNA etc.) for the treatment of brain cancer.

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Building 3D brain organoid models of brain cancer to improve early screening methods for nanotheragnostics

 Supervisor Dr Ruirui Qiao

Brain cancer is the leading cause of cancer related mortality in people under the age of 40. The design and synthesis of original, more targeted therapeutics, as well as the development of clinically relevant in vitro test models of brain cancer is urgently needed. For this project, you will build and characterise the formation and structural identity of a brain cancer organoid. The organoid that you develop will ultimately be used as a state-of-the art test platform for future in vitro studies; studies that are aimed at determining the efficacy of a theragnostic nanoparticle-siRNA therapeutic specifically designed and developed to target brain cancers. 

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Design and development of representative brain organoids during health and following the progressive establishment of Alzheimer’s disease

 Supervisor Dr Ruirui Qiao

Alzheimer’s disease is a progressive neurodegenerative disease that leads to severe cognitive decline. Alzheimer’s can develop in adults at any time, although onset is most associated with people over the age of 65. A full picture of what causes Alzheimer’s pathogenesis is still to be determined and as it stands, there is no definitive cure. Therefore, the development of more sophisticated clinically replicative in vitro test models of Alzheimer’s disease for the examination of new therapies that can inhibit, slow down disease progression, or readily complement existing treatment regimens are paramount. For this project, you will build a 3D brain organoid model encompassing Alzheimer’s disease effected neuronal cells. The aims of the project will be to characterise the effect of disease progression and investigate how this affects the architecture of the organoid brain model over time. The information obtained from this project will help to determine whether these organoids are a highly realistic in vitro model of Alzheimer’s disease and if they can be used as a test platform for future Alzheimer’s specific nanoparticle led treatments strategies.

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Multifunctional 3D Printing technique for magnetic resonance imaging (MRI)-guided regenerative medicine

 Supervisor Dr Ruirui Qiao, Professor Thomas P. David and Dr Liwen Zhang

3D printing technology has provided a promising tool for manufacturing customized scaffolds in tissue engineering and regenerative medicine applications. However, in situ imaging methods and probes are needed to monitor the scaffold-induced tissue regeneration. Recent advances in the development of novel functional nanoparticle integrated 3D-printing materials have shown great promises in tissue regeneration, disease diagnosis, and therapy owing to their unique properties. Among the various types of nanoparticles, magnetic iron oxide nanoparticles are promising tools for their unique magnetic properties. Integration of magnetic nanoparticles will significantly improve the functional properties of 3D printed scaffold. This project will focus on the development of novel magnetic nanoparticle/stereolithography 3D printing polymeric biomaterials for MRI-guided bone regeneration and magnetically-actuated implants.

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Bio-inspired magnetic nanotracers for single cell tracking

 Supervisor Dr Ruirui Qiao, Professor Thomas P. David and Dr Meihua Luo

Live cell imaging allows the visualisation of cellular process in real time. Imaging of cell trafficking will provide critical information regarding the cell fate and functions in a highly dynamic biological process. Ideally, single-cell would be tracked continuously and quantitatively from live to dead, which is a grand challenge in biological research ranging from tissue regeneration to gene- and cell-based therapeutic agents. Thus, the development of single-cell imaging and tracking tools is critically demanded to solve decades-long controversies regarding to dynamic molecular processes and mechanisms in cell processes. This project aims to develop a bio-inspired magnetic nanotracer for effective cell labelling and single cell tracking using molecular imaging techniques.

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Group Leader: Dr Ruirui Qiao
   07 334 63152
  r.qiao@uq.edu.au

What to do

  1. Review each project description and find one which matches your areas of interest.
  2. Contact the project advisor directly to discuss the project and arrange a meeting or visit to the AIBN lab.

Contact 

AIBN Engagement Officer
aibn.events@uq.edu.au
07 334 64215

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