Project Summary

Polymer Brush Model
Polymer Brush Model
This project focuses on understanding adult stem cells dysfunction in self-renewal and lineage potential occurring with ageing. The main hypothesis behind this change of behaviour is the modification of both the local and the systemic factors present in the niches. Polymer brush interfaces could allow stem cells in vitro manipulation mimicking the complexities of stem cell-niche interactions, by using polymer brush itself or bioactive properties of additionally attached biological cues. Our goal is to gain further insights into the complex regulation of adult stem cell maintenance to unravel the processes of generalized tissue degeneration associated with ageing.

Research Group

UQ-StemCARE

Keywords

stem cells, ageing, tissue engineering, gene delivery, polymer science

Project members

Lead Investigator


Dr Naatasha Isahak

Postdoctoral Research Fellow
UQ-StemCARE

Researchers Involved


Professor Justin Cooper-White

Senior Group Leader
Cooper-White Group
UQ-StemCARE Director

Professor Ernst Wolvetang

Senior Group Leader
Wolvetang Group
UQ-StemCARE Director