Genetic and epigenetic manipulations of neural stem cells and ageing
Duration:
March 2017–December 2019
Project Summary
Modeling ageing with iPSCs. Proliferating iPSCs from a patient with DNA repair mechanism impairments.
This project tests relevant genetic and epigenetic targets in the context of ageing. Specifically, we want to know how neural stem cell (NSC) niches respond after genetic and epigenetic manipulations, and whether such changes translate to measurable behaviours. This work is done using neuroprecursors from iPSC lines, in vivo mouse studies, and primary neuronal stem cells. Cumulatively, new insights from this work can inform the development of future drug targets for rejuvenation of NSC niches, as well as their local and hierarchal effects on health-span and ageing phenotypes. Finally, these studies will also unravel unexplored genetic and epigenetic targets that are involved in neuroprotection of age-related diseases.
