Mechano-driven changes to cardiac tissue function during ageing

Heart failure with preserved ejection fraction (HFpEF) is fast becoming the dominant mode of heart failure globally, primarily a result of our ageing population. Whilst there are many possible causative factors underlying HFpEF, fibrosis is a dominant impactor on the observed diastolic functional loss in the elderly population. Using both mouse and human models, this project focusses on understanding the drivers behind the onset and persistence of fibrosis in the cardiovascular system and the potential for Mechano-Medicine as a therapeutic strategy.