Heart failure with preserved ejection fraction (HFpEF) is fast becoming the dominant mode of heart failure globally, primarily a result of our ageing population. Whilst there are many possible causative factors underlying HFpEF, fibrosis is a dominant impactor on the observed diastolic functional loss in the elderly population. Using both mouse and human models, this project focusses on understanding the drivers behind the onset and persistence of fibrosis in the cardiovascular system and the potential for Mechano-Medicine as a therapeutic strategy.

Project members

Researchers Involved


Professor Ernst J. Wolvetang

Senior Group Leader
Wolvetang Group
UQ-StemCARE Director