Study

Biocompatible delivery systems allow enhanced delivery of pharmaceuticals, vaccines and other biological payload molecules, with varied effects including extending the pharmaceutical half-life of drugs, increasing adsorption and decreasing immunogenicity. While these agents have increased the efficacy of many biological therapies, very little work has been done on improving the targeting of these agents to the specific cell or receptor of interest. This project will examine strategies to increase the selectivity of biopolymer delivery systems to enhance the ability to target specific cell types or receptors, thereby reducing off target effects. This project will identify the chemical composition and biophysical characteristics of different cell membranes, and how this impacts their interaction with biopolymer delivery systems. The project requires good collaboration skills, an broad understanding of chemistry and biochemistry, and strong skills in multiscale modelling techniques, from QMMM to coarse grained molecular dynamics.