Cheetham Group

Next generation RNA vaccines and therapeutics

The Cheetham Group’s research program focuses on next generation RNA vaccines and therapeutics. mRNA technologies are a new paradigm for therapy and vaccinology; however, their full potential is yet to be realised.

First-generation mRNA vaccines have simple designs that do not yet take advantage of the latest advances in RNA sciences. We use approaches including modified nucleotides, RNA structural elements, high-throughput screening, circularisation, and transcriptomics to improve the properties of therapeutic RNAs.

The mRNAs that the Cheetham Group designs are used in diverse applications including vaccines, cellular reprogramming, and onco-immunology to treat intractable diseases.

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